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Zolpidem, with brand name of Ambien is a sedative-hypnotic (sleep) medicine indicated for the short term treatment of insomnia characterized by difficulties with sleep initiation. This drug has been shown to put patient to sleep more rapidly and keep them asleep much longer. It is commonly prescribed to patients with insomnia is brought about by anxiety, pain, daytime naps, evening exercises, depression, menopause and also by other drugs. Sleeping medications generally are not prescribed for more than 10 days and are usually taken intermittently as needed to avoid problems with addiction or habituation, loss of effectiveness, and rebound phenomena Ambien acts by binding to the benzodiazepine receptors, which is the major modulatory site for the GABA receptor complex. Subunit modulation of the GABA receptor complex is hypothesized to be responsible for sedative, anticonvulsant, anxiolytic and myorelaxant drug properties. It has a selective affinity to BZD receptors prevalent in the cerebellum (omega-1 receptors). It has strong sedative actions but only minor anxiolytic properties. It has also fewer effects on skeletal muscle and seizure threshold. An adverse effect of the drug may be but is not limited to daytime drowsiness, dizziness, lightheadedness, constipation, diarrhea, and dry mouth. Although unlikely, this drug can infrequently cause memory loss. Serious side effects include fast/pounding heartbeat, unusual tiredness, new or worsening depression, mental/mood changes, unsteadiness. Chest pain is a very serious side effect along with allergic reactions as rash, itching, swelling, severe dizziness, and difficulty of breathing.
There is increased sedation and incoordination when the drug is taken with Tricyclic Antidepressants (TCA), haloperidol and alcohol, with reduced effect when taken in conjunction with rifampicin. It is necessary that prior to prescription of the drug, the physician is made aware of all other drugs taken by the client.
Ambien should not be taken if the client drinks alcohol with precautions of taking it exactly as prescribed by the physician. It is best taken right before going to bed since decrease in the wakefulness brought about by the drug can result to accidents if any further activities are performed. Do not give Ambien unless the client can stay in bed for 7-8 hours. Further advise the client not to drive or operate any machinery after taking Ambien.
